Study of Laryngo-Pharyngeal Reflux (LPR) Disease and Combination Medical Treatment of Anti - Acid and Leukotriene Receptor Antagonist

Background: Laryngo-pharyngeal reflux disease and laryngo-pharyngeal symptoms and signs are common and increasing disorder mainly in pediatric patients. Frequency of LPR with laryngeal-pharyngeal issues and its response to combination or multiple medical treatment need to be clarified.

Objective: To determine the singes and symptoms LPR in Pediatric patients and to assess its response to combination of medical treatment with anti-acid (H2RA/PPI) and leukotriene receptor antagonist like (Singular; montelukast).

Method: 650 patients were diagnosed as having LPR and medical therapy was given for most of them. then the effect of 1 month of combination treatment of anti-acidand leukotriene receptor antagonist was assessed.

Results: male patients formed 65% of all patients, most of patients have nasal obstruction with snoring and nocturnal cough and vomiting with throat discomfort and above 90% of them improved almost completely and significantly (p> 0.001) on this treatment especially snoring,nocturnal cough, vomiting and voice quality issues after combination treatment for 1 month.

Conclusion: LPR is an increasing disease in pediatric patients may be due newly changing of life style, bad feeding habits in Arab Gulf Ares ,allergy to food, and there was positive impact that combination medical treatment reduce the need for further prolonged treatment and more investigations.

Keywords: OSA - GERD -LPR- VTI - IDL- RAOM - URT-H2RA - PPI - MZH.